HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intestinal iron homeostasis and colon tumorigenesis.

Abstract
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths in industrialized countries. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Iron is an essential nutrient for cell growth. Iron overload caused by hereditary mutations or excess dietary iron uptake has been identified as a risk factor for CRC. Intestinal iron is tightly controlled by iron transporters that are responsible for iron uptake, distribution, and export. Dysregulation of intestinal iron transporters are observed in CRC and lead to iron accumulation in tumors. Intratumoral iron results in oxidative stress, lipid peroxidation, protein modification and DNA damage with consequent promotion of oncogene activation. In addition, excess iron in intestinal tumors may lead to increase in tumor-elicited inflammation and tumor growth. Limiting intratumoral iron through specifically chelating excess intestinal iron or modulating activities of iron transporter may be an attractive therapeutic target for CRC.
AuthorsXiang Xue, Yatrik M Shah
JournalNutrients (Nutrients) Vol. 5 Issue 7 Pg. 2333-51 (Jun 28 2013) ISSN: 2072-6643 [Electronic] Switzerland
PMID23812305 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Iron, Dietary
Topics
  • Animals
  • Carcinogenesis (drug effects, metabolism)
  • Colon (drug effects, metabolism)
  • Colorectal Neoplasms (etiology, pathology)
  • DNA Damage (drug effects)
  • Disease Models, Animal
  • Homeostasis
  • Humans
  • Intestinal Mucosa (metabolism)
  • Intestines (drug effects)
  • Iron Overload (metabolism)
  • Iron, Dietary (administration & dosage, pharmacokinetics)
  • Lipid Peroxidation (drug effects)
  • Oxidative Stress (drug effects)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: