Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma.
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| Abstract |
Microparticles (MPs) are known to be increased in various malignancies and are involved in tumor invasion, angiogenesis, coagulation, and metastasis. We investigated the plasma levels of annexin-V MPs (AV(+)MPs), platelet-derived MPs (PMPs), and endothelial-derived MPs (EMPs) in patients with melanoma (n=129) and in healthy controls (n=49). A functional coagulation test STA Procoag-PPL measuring the clotting time was performed on samples containing MPs to evaluate their procoagulant potential. The plasma levels of PMPs, EMPs, and AV(+)MPs were significantly higher, and the clotting time-PPL was significantly lower in melanoma patients than in healthy controls. The plasma levels of PMPs, EMPs, and AV(+)MPs were higher in stage IV than in the other stages of melanoma, but with no significant difference. In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis.
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| Authors | Claire Laresche, Fabien Pelletier, Francine Garnache-Ottou, Thomas Lihoreau, Sabeha Biichlé, Guillaume Mourey, Philippe Saas, Philippe Humbert, Estelle Seilles, François Aubin |
| Journal | The Journal of investigative dermatology (J Invest Dermatol) Vol. 134 Issue 1 Pg. 176-182 (Jan 2014) ISSN: 1523-1747 [Electronic] United States |
| PMID | 23812302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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