Abstract |
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has gained attention for its pro-inflammatory potential in atherogenesis. This study evaluates LOX-1 receptor modulation in the presence of an atheroprotective cytokine, interleukin-10 (IL-10). Both oxidized low-density lipoprotein ( oxLDL) and IL-10 stimulated LOX-1 cell surface expression on THP-1 macrophages. However, our study demonstrates differential roles of oxLDL and IL-10 on LOX-1 functionality. Seemingly, oxLDL-induced LOX-1 promoted pro-inflammatory signalling by increasing intracellular NO, a substrate for pro-inflammatory peroxynitrite. In contrast, IL-10-induced LOX-1 facilitated scavenging of extracellular oxLDL without any effect on pro-inflammatory signalling. The atheroprotective effects of IL-10 were demonstrated by both facilitation of cellular oxLDL uptake and expression of LOXIN, an atheroprotective haplotype of the LOX-1 gene. Thus, increased expression of IL-10 may help to attenuate the risk of atherosclerosis developed by pro-inflammatory signal(s) generated through the interaction of oxLDL with its cognate receptor LOX-1 on macrophages.
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Authors | Albina Arjuman, Nimai C Chandra |
Journal | Diabetes & vascular disease research
(Diab Vasc Dis Res)
Vol. 10
Issue 5
Pg. 442-51
(Sep 2013)
ISSN: 1752-8984 [Electronic] England |
PMID | 23811604
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL10 protein, human
- Lipoproteins, LDL
- OLR1 protein, human
- Scavenger Receptors, Class E
- oxidized low density lipoprotein
- Interleukin-10
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Topics |
- Atherosclerosis
(metabolism)
- Cells, Cultured
- Endothelial Cells
(metabolism)
- Humans
- Interleukin-10
(metabolism)
- Lipoproteins, LDL
(metabolism)
- Macrophages
(metabolism)
- Scavenger Receptors, Class E
(metabolism)
- Signal Transduction
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