Steroids in biliary atresia: single surgeon, single centre, prospective study.

Abstract

BACKGROUND & AIMS:

The effect of adjuvant steroids in infants with biliary atresia (BA) is not clear and evidence of benefit is lacking.

METHODS:

During the period Jan. 2000-Dec. 2011, 153 infants with isolated (CMV IgM-ve) BA underwent Kasai portoenterostomy (KPE) at<70 days. They were divided into three groups: LOW-dose steroid (from a previous randomized trial; starting prednisolone 2mg/kg/day, n=18), HIGH-dose steroid (starting prednisolone 5mg/kg/day, n=44), and NO steroid [n=72+19 placebo (from randomized trial)=91]. Outcome was assessed by early liver biochemistry, clearance of jaundice (<20 μmol/L), and actuarial native liver survival. Data are quoted as median (IQ range) and compared with non-parametric ANOVA, Chi or Log-rank tests as appropriate. p ≤ 0.05 was regarded as significant.

RESULTS:

All three groups were comparable for age (ANOVA, p=0.31) and a surrogate marker of liver fibrosis [aspartate-aminotransferase index (APRi), ANOVA, p=0.67]. At 1 month post KPE, there was a significant reduction in bilirubin [58 (25-91) vs. 91 (52-145)μmol/L, p=0.0015], AST [118 (91-159) vs. 155 (108-193)IU/L, p=0.0015], and APRi [0.49 (0.28-0.89) vs. 0.82 (0.45-1.2), p=0.005] for HIGH vs. NO steroid. There was a significant increase in % clearance of jaundice with the use of steroids [47/91 (52%) vs. 12/18 (67%) vs. 29/44 (66%); steroids vs. no steroids, p=0.037]. There was no statistical difference in 4-year patient survival (96% vs. 94% vs. 95%) or native liver survival (4 year=46% vs. 50 vs. 57%).

CONCLUSIONS:

The adjuvant use of prednisolone significantly improved early post-operative liver biochemistry (especially at the higher dose), and increased the proportion of infants who cleared their jaundice at 6 months post-KPE.

• Authors: Mark Davenport, Chris Parsons, Sarah Tizzard, Nedim Hadzic
• Journal: Journal of hepatology (J Hepatol) Vol. 59 Issue 5 Pg. 1054-8 (Nov 2013) ISSN: 1600-0641 [Electronic] Netherlands
• PMID: 23811305 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Chemical References

• Steroids
• Prednisolone
• Bilirubin

Topics

• Biliary Atresia (drug therapy, mortality, surgery)
• Bilirubin (metabolism)
• Chemotherapy, Adjuvant
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Humans
• Infant
• Portoenterostomy, Hepatic
• Prednisolone (therapeutic use)
• Prospective Studies
• Retrospective Studies
• Steroids (therapeutic use)
• Survival Rate
• Treatment Outcome