[The detection of leptin and metabolic markers of insulin resistance in patients with myocardial infarction].

Abstract

The shortage of data concerning the character of changes of leptin concentration and its role information of insulin resistance under development of acute coronary events determined the appropriateness of the present study. The cardiac infarction patients with and without diabetes type II were examined. The identified hyperleptinemia, its relationship with basal and post-prandial hyperglycemia and with increase of C-peptide concentration and free fatty acids made possible to consider leptin both as one of the important components in the series of carbohydrate and lipid metabolism disorders and the additional marker of development of insulin resistance under cardiac infarction. These study results can be applied to patients with diabetes anamnesis and to patients without this concomitant pathology. The study results can be used as a foundation for new diagnostic and therapy tactics of metabolic disorders correction in patients with acute coronary vascular pathology.

• Authors: O V Gruzdeva, O L Barbarash, O E Akbasheva, E I Palicheva, Iu A Dyleva, E V Belik, E G Uchasova, V N Karetnikova, V V Kashtalap
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 2 Pg. 12-6 (Feb 2013) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 23808002 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Blood Glucose
• C-Peptide
• Insulin
• Leptin

Topics

• Aged
• Biomarkers (blood, metabolism)
• Blood Glucose (metabolism)
• Body Mass Index
• C-Peptide (blood)
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications, metabolism)
• Female
• Humans
• Insulin (blood)
• Insulin Resistance
• Leptin (blood)
• Male
• Middle Aged
• Myocardial Infarction (blood, complications, metabolism)