Abstract | OBJECTIVE: To investigate the effects of enriched environment and impoverished environment on the learning and memory ability of manganese-exposed mice and the mechanism. METHODS: RESULTS: In place navigation test, the SEG had a significantly longer escape latency than the CG (P < 0.05), and the EEG had a significantly shorter escape latency than the SEG (P < 0.05); there was no significant difference in escape latency between IEG and SEG (P > 0.05). In spatial probe test, the EEG had a significantly greater number of platform crossings than the SEG (P < 0.05), and the IEG had a significantly smaller number of platform crossings than the SEG (P < 0.05). The expression of CREB in area CA1 of the hippocampus was significantly lower in IEG and SEG than in CG (P < 0.05), and it was significantly higher in EEG than in SEG (P < 0.05). CONCLUSION: In the enriched environment, the learning and memory ability of manganese-exposed mice can be improved, which may be due to the increased expression of CREB in the hippocampus.
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Authors | Zhong-xin Guo, Wen-yu Li, Jun-ran Li, Hong-lin Li, Ke Wei, Bo-ning Yang |
Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
(Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)
Vol. 31
Issue 6
Pg. 409-12
(Jun 2013)
ISSN: 1001-9391 [Print] China |
PMID | 23803537
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclic AMP Response Element-Binding Protein
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Topics |
- Animals
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Disease Models, Animal
- Environment
- Female
- Hippocampus
(drug effects, metabolism)
- Learning
(drug effects)
- Manganese Poisoning
(metabolism)
- Memory
(drug effects)
- Mice
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