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[Efficacy of treatment with I(131) in paediatric Graves disease].

AbstractINTRODUCTION:
Radioiodine is an important therapeutic option in young patients with Grave's disease (GD). In the United States it is a widespread therapy, but in Europe its use in paediatrics is still controversial.
AIM:
To report our experience in radioiodine therapy of paediatric GD patients and analyse its effectiveness and safety.
PATIENTS AND METHODS:
We retrospectively studied our paediatric population (<18 years of age) with GD, diagnosed from 1982 to 2012. A curative option was offered to patients who did not respond to anti-thyroid drug (AT) at puberty. We analysed, the patient characteristics, TSH, T4, T3 and thyroid antibodies levels, AT response, remission post I(131), side effects, and hypothyroidism rates.
RESULTS:
A total of 50 patients were diagnosed with GD from 1982 to 2012. All patients received AT as initial treatment (mean duration: 35.3±25.9 months). Permanent remission was achieved in 46%. Thyroidectomy was performed in 5 patients, and 14 patients received I(131) (mean dose: 10.9±1.09 mCi). Remission with I(131) was obtained in 100%. The rate of permanent hypothyroidism was 90%. There was no progression of ophthalmopathy or side effects in any patients treated with I(131.)
CONCLUSION:
Radioiodine treatment of paediatric GD patients is safe, leads to complete remission at the expense of hypothyroidism, and does not exacerbate ophthalmopathy. It can be considered in patients older than 5 years, who do no not respond to AT or with significant side effects with this medication.
AuthorsP Enes Romero, M Martín-Frías, M de Jesús, C Caballero Loscos, M Alonso Blanco, R Barrio Castellanos
JournalAnales de pediatria (Barcelona, Spain : 2003) (An Pediatr (Barc)) Vol. 80 Issue 1 Pg. 16-20 (Jan 2014) ISSN: 1695-9531 [Electronic] Spain
Vernacular TitleEficacia del tratamiento con (131)I en la enfermedad de Graves pediátrica.
PMID23796613 (Publication Type: English Abstract, Journal Article)
CopyrightCopyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.
Chemical References
  • Iodine Radioisotopes
Topics
  • Child
  • Female
  • Graves Disease (radiotherapy)
  • Humans
  • Iodine Radioisotopes (therapeutic use)
  • Male
  • Retrospective Studies
  • Treatment Outcome

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