Novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone – case report.

Abstract

Rhinosporidiosis is a chronic granulomatous disorder, caused by Rhinosporidium seeberi endemic in India and Sri Lanka. The most common sites are the nasal mucosa and the nasopharynx and cutaneous lesions usually occur as a part of disseminated rhinosporidiosis. Dapsone has been frequently used in treating disseminated disease in immunocompetent individuals. Here we report a case of disseminated rhinosporidiosis in an immunocompromised individual on antiretroviral drugs, non-responsive to Dapsone and therefore treated with a multidrug therapy of Cycloserine, Dapsone and Ketoconazole with good response.

• Authors: Leni George, Peter Dincy, Manu Chopra, Manoj Agarwala, S Maheswaran, Divya Deodhar, Priscilla Rupali, Meera Thomas, Susanne Pulimood
• Journal: Tropical doctor (Trop Doct) Vol. 43 Issue 3 Pg. 110-2 (Jul 2013) ISSN: 1758-1133 [Electronic] England
• PMID: 23796478 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Dapsone
• Cycloserine
• Ketoconazole

Topics

• Anti-Infective Agents (administration & dosage)
• Cycloserine (administration & dosage)
• Dapsone (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Humans
• Ketoconazole (administration & dosage)
• Male
• Middle Aged
• Rhinosporidiosis (drug therapy)