Abstract | BACKGROUND: METHODS: A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres. RESULTS: The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02). CONCLUSION: In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation.
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Authors | Kristin Baumann, Petra Beuter-Winkler, Andreas Hackethal, Thomas Strowitzki, Bettina Toth, Michael K Bohlmann |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 70
Issue 6
Pg. 518-21
(Dec 2013)
ISSN: 1600-0897 [Electronic] Denmark |
PMID | 23795816
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Chemical References |
- factor V Leiden
- Factor V
- Prothrombin
- Methylenetetrahydrofolate Reductase (NADPH2)
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Topics |
- Abortion, Habitual
(enzymology, genetics)
- Adult
- Cohort Studies
- Factor V
(genetics)
- Female
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
(genetics)
- Mutation
- Polymorphism, Genetic
(genetics)
- Prothrombin
(genetics)
- Retrospective Studies
- White People
(genetics)
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