Contrast-enhanced high-frequency ultrasound imaging of early stage liver metastasis in a preclinical mouse model.

Abstract

Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional CE-HFUS detected an increase in blood vessel density in the liver after intrasplenic injection of breast tumor cells into mice. The results were in agreement with immunohistochemical analysis of blood vessel density. Three-dimensional CE-HFUS using microbubbles is an attractive, novel approach for the early detection of liver metastases through quantification of new, pathological vascular growth (i.e. tumor angiogenesis).

• Authors: Sachiko Horie, Rui Chen, Li Li, Shiro Mori, Tetsuya Kodama
• Journal: Cancer letters (Cancer Lett) Vol. 339 Issue 2 Pg. 208-13 (Oct 10 2013) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 23791880 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Contrast Media

Topics

• Animals
• Contrast Media
• Disease Models, Animal
• Disease Progression
• Imaging, Three-Dimensional
• Liver (blood supply, pathology)
• Liver Neoplasms (diagnostic imaging, pathology, secondary)
• Male
• Mice
• Microbubbles
• Neoplasm Staging
• Ultrasonography