Effect of dietary fat and monoclonal antibody therapy on the growth of human mammary adenocarcinoma MX-1 grafted in athymic mice.

Abstract

A diet containing 11% per weight fish oils (Max-EPA) reduced the rate of growth of a transplantable human breast tumor (MX-1) grafted into immunodeficient mice (BALB/c, nu/nu) when compared to MX-1 tumors in mice fed polyunsaturated (corn oil) and saturated (lard) fatty acids; however, there was no difference between the corn oil and lard animal groups. Treatment with a cocktail of monoclonal antibodies (MoAbs) decreased the rat of growth of MX-1 in the corn oil fed animals but not in those fed lard or Max-EPA, but the rate of tumor growth of the Max-EPA treated group, either MoAb treated or not, was slower than that of the corn oil and lard groups.

• Authors: H Gabor, E W Blank, R L Ceriani
• Journal: Cancer letters (Cancer Lett) Vol. 52 Issue 3 Pg. 173-8 (Jul 31 1990) ISSN: 0304-3835 [Print] Ireland
• PMID: 2379141 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Monoclonal
• Dietary Fats
• Fish Oils

Topics

• Adenocarcinoma (diet therapy, therapy)
• Animals
• Antibodies, Monoclonal (therapeutic use)
• Breast Neoplasms (diet therapy, therapy)
• Cell Line
• Dietary Fats
• Female
• Fish Oils (therapeutic use)
• Humans
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Transplantation, Heterologous