Abstract | OBJECTIVE: METHODS: Twenty-six pediatric patients with relapsed/refractory acute lymphoblastic leukemia were treated with clofarabine. There were 22 males and 4 females, with a mean age of 9.5 years (ranging from 4 to 17 years). They received clofarabine 52 mg/m2 intravenously over 2 hours daily for 5 days. Thirteen patients received two cycles and one patient received three cycles. RESULTS: In the first cycle of clofarabine, complete remission was obtained in 11 children (42%) and partial remission was obtained in 7 children (27%). Eight children (31%) were considered unresponsive. In the second cycle, 11 (85%) of the 13 children obtained complete remission, 1 (8%) partial remission and 1 (8%) was unresponsive. One child received three cycles and obtained complete remission in each cycle. The common adverse events were myelosuppression, infection, liver dysfunction and gastrointestinal adverse reactions. There were no chemotherapy-related deaths. CONCLUSIONS:
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Authors | Pan Suo, Le-Ping Zhang, Jun Wu, Ai-Dong Lu, Bin Wang, Ying-Xi Zuo, Yi-Fei Cheng, Gui-Lan Liu |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 15
Issue 6
Pg. 444-7
(Jun 2013)
ISSN: 1008-8830 [Print] China |
PMID | 23791059
(Publication Type: Journal Article)
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Chemical References |
- Adenine Nucleotides
- Antineoplastic Agents
- Arabinonucleosides
- Clofarabine
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Topics |
- Adenine Nucleotides
(adverse effects, therapeutic use)
- Adolescent
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Arabinonucleosides
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Clofarabine
- Female
- Follow-Up Studies
- Humans
- Infant
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy)
- Recurrence
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