Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats.

Abstract

Sclerosing cholangitis has been reported after surgical treatment of hydatid disease of the liver and has been hypothetically attributed to the caustic effect of the parasiticide solution injected into the cyst and diffusing into the biliary tree through a cystic-biliary fistula. In this experimental study, we showed that, in rats, injection into the biliary tract of 20% hypertonic saline solution or 2% formaldehyde solution, the most commonly used scolicidal solutions, was followed by lesions of the biliary epithelium. As compared with 20% hypertonic saline solution, the 2% formaldehyde solution caused more severe lesions of the biliary epithelium and, in addition, induced the development of sclerosis. This experimental study confirms the deleterious effect of scolicidal solutions to the biliary epithelium, shows that their effect is mainly related to the causticity of the scolicidal solution, and indicates that intracystic injection of 2% formaldehyde solution should be abandoned.

• Authors: S Houry, O Languille, M Huguier, J P Benhamou, J Belghiti, S Msika
• Journal: Archives of surgery (Chicago, Ill. : 1960) (Arch Surg) Vol. 125 Issue 8 Pg. 1059-61 (Aug 1990) ISSN: 0004-0010 [Print] United States
• PMID: 2378559 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Saline Solution, Hypertonic
• Formaldehyde

Topics

• Animals
• Cholangitis, Sclerosing (chemically induced, pathology)
• Common Bile Duct (pathology)
• Disease Models, Animal
• Duodenum (pathology)
• Echinococcosis, Hepatic (drug therapy)
• Epithelium (injuries, pathology)
• Formaldehyde (adverse effects, therapeutic use)
• Liver (pathology)
• Rats
• Rats, Inbred Strains
• Saline Solution, Hypertonic (adverse effects, therapeutic use)