Therapeutic effect of prolonged treatment with topical dorzolamide for cystoid macular oedema in patients with retinitis pigmentosa.

Abstract

AIM:

To evaluate the therapeutic effect of continuous treatment with topical dorzolamide (a carbonic anhydrase inhibitor) for cystoid macular oedema (CME) associated with retinitis pigmentosa (RP).

METHODS:

18 eyes in 10 patients with CME secondary to RP were included. Baseline visual acuity, visual field and optical coherence tomography (OCT) measurements were obtained for all patients. All patients used 1% dorzolamide three times daily in each affected eye. Patients underwent follow-up examinations at 1, 3, 6, 12 and 18 months after treatment. The response to treatment was monitored by the Humphrey field analyser (HFA: the central 10-2 program); in addition, foveal thickness was measured by OCT. Evaluation of 'macular sensitivity' was calculated by HFA as the average of 12 central points.

RESULTS:

The 'macular sensitivity' in 10 eyes in which CME was almost completely resolved was significantly improved (p<0.05). In eight of the nine eyes in which CME was almost completely resolved within 6 months, the therapeutic efficacy persisted through 18 months. Five eyes which were almost completely resolved or showed an initial response within 6 months experienced recurrence of CME.

CONCLUSIONS:

The prolonged (longer than 1 year) use of topical dorzolamide is effective for the treatment of CME in patients with RP. Therefore, we propose topical dorzolamide treatment as a first choice.

• Authors: Yasuhiro Ikeda, Noriko Yoshida, Shoji Notomi, Yusuke Murakami, Toshio Hisatomi, Hiroshi Enaida, Tatsuro Ishibashi
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 97 Issue 9 Pg. 1187-91 (Sep 2013) ISSN: 1468-2079 [Electronic] England
• PMID: 23782868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Carbonic Anhydrase Inhibitors
• Sulfonamides
• Thiophenes
• dorzolamide

Topics

• Administration, Topical
• Adult
• Antihypertensive Agents (administration & dosage)
• Carbonic Anhydrase Inhibitors (administration & dosage)
• Female
• Humans
• Macular Edema (drug therapy, etiology, pathology)
• Male
• Middle Aged
• Prospective Studies
• Retinitis Pigmentosa (complications)
• Sulfonamides (administration & dosage)
• Thiophenes (administration & dosage)
• Time Factors
• Tomography, Optical Coherence
• Young Adult