Abstract | PURPOSE OF REVIEW: The purpose of this review is to examine recently published literature in the areas of incretins and amylin in the management of pediatric diabetes. RECENT FINDINGS: SUMMARY: Very few medications are approved for management of type 2 diabetes in youth. In addition, monotherapy of type 1 diabetes in youth with insulin does not achieve HbA1c targets in the majority of youth despite the use of rapid-acting insulin analogues, insulin pump therapy, and continuous glucose monitoring. Novel therapies that target physiologic modalities other than enhancing or replacing insulin secretion or improving insulin sensitivity have shown efficacy in adults. Studies with these drugs are being done in the pediatric population and should provide additional treatment options for these patients.
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Authors | Jamie R Wood, Janet Silverstein |
Journal | Current opinion in pediatrics
(Curr Opin Pediatr)
Vol. 25
Issue 4
Pg. 502-8
(Aug 2013)
ISSN: 1531-698X [Electronic] United States |
PMID | 23782574
(Publication Type: Journal Article, Review)
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Chemical References |
- Hypoglycemic Agents
- Incretins
- Islet Amyloid Polypeptide
- Glucagon-Like Peptide 1
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Topics |
- Adolescent
- Child
- Diabetes Mellitus, Type 1
(drug therapy)
- Diabetes Mellitus, Type 2
(drug therapy)
- Disease Management
- Glucagon-Like Peptide 1
(analogs & derivatives, therapeutic use)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Incretins
(therapeutic use)
- Islet Amyloid Polypeptide
(therapeutic use)
- Pediatric Obesity
(drug therapy)
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