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Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.

AbstractBACKGROUND:
Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures.
METHODS:
A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials.
RESULTS:
A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions.
CONCLUSION:
Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight into the collaborative approach applied to orphan diseases, of which chordomas is a prime exemplar.
AuthorsSalvatore Di Maio, Esther Kong, Stephen Yip, Robert Rostomily
JournalSurgical neurology international (Surg Neurol Int) Vol. 4 Pg. 72 ( 2013) ISSN: 2229-5097 [Print] United States
PMID23776758 (Publication Type: Journal Article)

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