Abstract | INTRODUCTION: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemisinin derivatives used for the treatment of malaria also have an antischistosomal effect. This study aimed to investigate the extent of malaria- schistosomiasis co-infection and the antischistosomal effect of artemether-lumefantrine when administered to treat falciparum malaria in Kemise, Northeast Ethiopia. METHODOLOGY: RESULTS: Twenty-eight out of 152 malaria patients were co-infected (18.4%, n = 152) with schistosomiasis. All 28 co-infected patients were found stool-negative for Schistosoma mansoni eggs four weeks after treatment. The extent of co-infection was associated with age, sex and educational level. Cure rate and egg reduction rate following the treatment of artemether-lumefantrine were 100%. CONCLUSION:
|
Authors | Solomon M Abay, Mulugeta Tilahun, Nigus Fikrie, Abiy Habtewold |
Journal | Journal of infection in developing countries
(J Infect Dev Ctries)
Vol. 7
Issue 6
Pg. 468-74
(Jun 15 2013)
ISSN: 1972-2680 [Electronic] Italy |
PMID | 23771290
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anthelmintics
- Antimalarials
- Artemether, Lumefantrine Drug Combination
- Artemisinins
- Drug Combinations
- Ethanolamines
- Fluorenes
|
Topics |
- Adolescent
- Adult
- Animals
- Anthelmintics
(therapeutic use)
- Antimalarials
(therapeutic use)
- Artemether, Lumefantrine Drug Combination
- Artemisinins
(therapeutic use)
- Child
- Coinfection
(epidemiology, parasitology, pathology)
- Drug Combinations
- Ethanolamines
(therapeutic use)
- Ethiopia
(epidemiology)
- Feces
(parasitology)
- Female
- Fluorenes
(therapeutic use)
- Humans
- Malaria, Falciparum
(complications, epidemiology, parasitology, pathology)
- Male
- Middle Aged
- Parasite Egg Count
- Plasmodium falciparum
(isolation & purification)
- Schistosoma mansoni
(isolation & purification)
- Schistosomiasis mansoni
(complications, epidemiology, parasitology, pathology)
- Young Adult
|