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Efficacy of lacosamide on seizures and myoclonus in a patient with epilepsia partialis continua.

Abstract
A 39-year-old male with epilepsia partialis continua, refractory to first- and second-line antiepileptic drugs, is described. Lacosamide produced a progressive antiepileptic effect on Jacksonian motor seizures and subsequently on positive myoclonus, which developed into negative myoclonus before complete resolution. Our report confirms the efficacy of lacosamide on focal motor refractory status epilepticus and documents a unique effect of lacosamide on seizure semiology.
AuthorsMaddalena Spalletti, Angela Comanducci, Alessandro Vagaggini, Luca Bucciardini, Antonello Grippo, Aldo Amantini
JournalEpileptic disorders : international epilepsy journal with videotape (Epileptic Disord) Vol. 15 Issue 2 Pg. 193-6 (Jun 2013) ISSN: 1294-9361 [Print] France
PMID23761109 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Acetamides
  • Anticonvulsants
  • Lacosamide
Topics
  • Acetamides (therapeutic use)
  • Adult
  • Anticonvulsants (therapeutic use)
  • Epilepsia Partialis Continua (drug therapy, etiology)
  • Hematoma, Subdural (complications)
  • Humans
  • Lacosamide
  • Male

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