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Hemodynamic and volume changes by recombinant human erythropoietin (rHuEPO) in the treatment of anemic hemodialysis patients.

Abstract
Hemodynamic and volume changes induced by recombinant human erythropoietin (rHuEPO) treatment were investigated in 12 chronic hemodialysis patients with refractory anemia. After rHuEPO administration for 49 to 151 days, hematocrit (Ht) significantly improved from 19.4 +/- 2.3 to 30.1 +/- 1.1% (Mean +/- SD). Mean blood pressure (MBP) increased slightly but significantly from 78.8 +/- 13.2 to 88.9 +/- 16.9 mmHg. Hemodynamically, total peripheral resistance index (TPRI) increased significantly from 1,444 +/- 367 to 2,146 +/- 470 dynes.sec.cm-5.m2, while cardiac index (CI) decreased significantly from 4.49 +/- 0.85 to 3.37 +/- 0.60 l/min/m2. Both pulse rate (PR) and stroke volume index (SVI) also decreased significantly, but blood volume (BV) remained unchanged. Plasma renin activity and plasma norepinephrine decreased significantly. There were positive correlations between the change of MBP and that of CI, and between the change in CI and that of BV, respectively (p less than 0.05 or less). In conclusion the improvement of anemia using rHuEPO is hemodynamically associated with an increase in TPRI and a decrease in CI as well. Blood pressure elevation seems to be caused by an inappropriately minor reduction of CI. The contribution of humoral factors is not suggested.
AuthorsK Hori, K Onoyama, K Iseki, S Fujimi, M Fujishima
JournalClinical nephrology (Clin Nephrol) Vol. 33 Issue 6 Pg. 293-8 (Jun 1990) ISSN: 0301-0430 [Print] Germany
PMID2376091 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Recombinant Proteins
  • Erythropoietin
Topics
  • Adult
  • Anemia (drug therapy, etiology)
  • Blood Pressure (drug effects)
  • Erythropoietin (adverse effects, therapeutic use)
  • Female
  • Hematocrit
  • Hemodynamics (drug effects)
  • Humans
  • Hypertension (chemically induced)
  • Kidney Failure, Chronic (complications, therapy)
  • Male
  • Recombinant Proteins (adverse effects, therapeutic use)
  • Renal Dialysis
  • Time Factors

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