Abstract | OBJECTIVE: DESIGN: Prospective explorative study. SETTING: Academic tertiary care center. PATIENT(S): Eighty symptomatic patients scheduled for laparoscopy for the diagnosis and/or therapy of endometriosis. INTERVENTION(S): Aspiration of PF samples during laparoscopy. MAIN OUTCOME MEASURE(S): RESULT(S): At laparoscopy, 47 of 80 (58.8%) patients exhibited endometriosis, and 33 (41.2%) were proven disease-free (CO). By means of ELISA significantly lower concentrations of hemopexin in the samples from patients with endometriosis ( endometriosis 0.377 ± 0.16 mg/mL) compared with controls (disease-free 0.479 ± 0.20 mg/mL) could be demonstrated. Heme levels in the samples were not significantly different between groups ( endometriosis 9.130 ± 6.124 μM and disease-free 9.990 ± 4.485 μM). There was no significant correlation between heme and hemopexin levels (Pearson's correlation coefficient r = -0.146). Demographic data between the groups were comparable. CONCLUSION(S): These data provide further evidence that hemopexin is significantly down-regulated in PF samples from patients with endometriosis compared with controls. This study confirms recent findings in two-dimensional gel electrophoresis demonstrating a down-regulation of hemopexin in PF from patients with endometriosis in a larger series of samples.
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Authors | Monika M Wölfler, Ivo M Meinhold-Heerlein, Corinna Henkel, Werner Rath, Joseph Neulen, Nicolai Maass, Karen Bräutigam |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 100
Issue 3
Pg. 777-81
(Sep 2013)
ISSN: 1556-5653 [Electronic] United States |
PMID | 23755951
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Ascitic Fluid
(chemistry, metabolism, pathology)
- Down-Regulation
- Endometriosis
(metabolism, pathology, surgery)
- Enzyme-Linked Immunosorbent Assay
- Female
- Heme
(analysis, metabolism)
- Hemopexin
(analysis, metabolism)
- Humans
- Laparoscopy
- Ovarian Diseases
(metabolism, pathology, surgery)
- Young Adult
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