Oncologic outcomes after adjuvant chemotherapy using FOLFOX in MSI-H sporadic stage III colon cancer.

Abstract

BACKGROUND:

Little is known of the oncological outcomes after adjuvant FOLFOX chemotherapy in patients with stage III colon cancer showing microsatellite instability high (MSI-H). In the present study we investigated the prognostic impact of MSI-H in patients with stage III colon cancer receiving FOLFOX chemotherapy.

METHODS:

We analyzed the MSI status in 127 patients with stage III colon cancer who underwent curative surgical resection followed by FOLFOX chemotherapy between January 2003 and December 2010. We assessed disease-free and overall survival (OS) in patients with MSI-H colon cancer compared with those showing microsatellite instability low or microsatellite stable (MSI-L/MSS) disease.

RESULTS:

Sixteen of the patients (12.6 %) were MSI-H, and 111 patients (87.4 %) were MSI-L/MSS. There was no significant difference between patients showing MSI-H and MSI-L/MSS except for age (P = 0.030), tumor location (P < 0.001), and differentiation (P = 0.031). Compared with MSI-L/MSS colon cancer, patients with MSI-H colon cancer had no significant difference in 5-year disease-free and OS (72.2 vs 68.5 %, P = 0.874; 68.1 vs 71.1 %, P = 0.437).

CONCLUSIONS:

Our study indicates that FOLFOX chemotherapy can be considered to treat stage III colon cancer patients with MSI-H after surgery, although the study was not randomized and included only a limited number of patients.

• Authors: Seung Yeop Oh, Do Yoon Kim, Young Bae Kim, Kwang Wook Suh
• Journal: World journal of surgery (World J Surg) Vol. 37 Issue 10 Pg. 2497-503 (Oct 2013) ISSN: 1432-2323 [Electronic] United States
• PMID: 23754140 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Leucovorin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Colectomy
• Colonic Neoplasms (drug therapy, genetics, pathology, surgery)
• Drug Administration Schedule
• Female
• Fluorouracil (therapeutic use)
• Follow-Up Studies
• Humans
• Leucovorin (therapeutic use)
• Male
• Microsatellite Instability
• Middle Aged
• Neoplasm Staging
• Organoplatinum Compounds (therapeutic use)
• Retrospective Studies
• Survival Analysis
• Treatment Outcome