Abstract | BACKGROUND: MATERIALS AND METHODS: Pathogen-free, female hairless mice of HOS:HR-1 strain, 15 animals per control and test groups, were used. Skin tumors were induced by a single dose of NOR-1 (390 nmol in 100 μl of acetone). One week later, TPA (1.7 nmol in 100 μl of acetone) was applied to skin twice weekly for 20 weeks as tumor a promoter. The test compounds UV-I or UV-2 were administered at 0.0025% to mice through drinking water ad libitum, starting one week prior to and stopping one week after tumor initiation. All animals were examined weekly for the development of skin papillomas. RESULTS: In both UV-1- and UV-2-treated mice, a two-week delay in tumor appearance, and significant inhibition (p<0.001) of tumor incidence (50% and 60%, respectively) and tumor burden ( papilloma inhibition/mouse, 50% and 70%, respectively) were observed when compared to the positive control group. UV-2 (dihydroxy derivative) was a more potent inhibitor of skin tumor than UV-1 (monohydroxy derivative), which followed their antioxidant activity ranking. CONCLUSION:
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Authors | G Subba Rao, Harukuni Tokuda, Eiichiro Ichiishi, Midori Takasaki, Akira Iida, Nobutaka Suzuki, Takao Konoshima, Govind J Kapadia |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 6
Pg. 2535-40
(Jun 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23749905
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticarcinogenic Agents
- Benzophenones
- Drinking Water
- Sunscreening Agents
- benzophenone
- dioxybenzone
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Topics |
- Animals
- Anticarcinogenic Agents
(administration & dosage, therapeutic use)
- Benzophenones
(administration & dosage, therapeutic use)
- Cell Transformation, Neoplastic
- Drinking Water
- Female
- Mice
- Mice, Hairless
- Skin Neoplasms
(drug therapy, prevention & control)
- Sunscreening Agents
(administration & dosage, therapeutic use)
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