Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure.

Abstract

BACKGROUND:

Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease.

MATERIALS AND METHODS:

A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation].

RESULTS:

eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05).

CONCLUSION:

SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD.

• Authors: Dede Sit, Taner Basturk, Süleyman Yildirim, Ferdi Karagoz, Nalan Bozkurt, Ayşegül Gunes
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 46 Issue 1 Pg. 57-62 (Jan 2014) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 23749031 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Cystatin C

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Cystatin C (blood)
• Female
• Glomerular Filtration Rate
• Humans
• Kidney Failure, Chronic (blood, physiopathology, therapy)
• Male
• Middle Aged
• Predictive Value of Tests
• Renal Dialysis
• Young Adult