Association between eprosartan-based hypertension therapy and improvement in cognitive function score: long-term follow-up from the OSCAR observational study.

The Observational Study on Cognitive function And systolic blood pressure Reduction (OSCAR) was designed to evaluate the impact of eprosartan-based therapy on cognitive function in a cohort of 25,745 hypertensive subjects followed for six months.
In this supplementary analysis, we studied the relationship between eprosartan-based therapy and cognitive function (assessed using the Mini-Mental State Examination (MMSE)) after 12-month follow-up of 3600 patients (the long-term follow-up on-treatment population).
Reduction in blood pressure was sustained over 12 months, with mean systolic blood pressure/diastolic blood pressure 130.9/79 mmHg at one year, compared with 164.3/92.8 mmHg at baseline (p<0.001). The overall mean MMSE score at completion of 12-month follow-up was significantly increased from baseline (27.8 ± 2.7 vs. 26.3 ± 3.5; p<0.001). The increase in MMSE score was observed when the population was stratified by age (p<0.001) and in a subgroup of patients with cerebrovascular disease at baseline (n=290) (p<0.001, 12 months vs. baseline).
In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline.
AuthorsOlivier Hanon, Yong-Seok Lee, Atul Pathak, OSCAR Publication Group
JournalJournal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 16 Issue 2 Pg. 366-73 (Jun 2015) ISSN: 1752-8976 [Electronic] England
PMID23748626 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
Copyright© The Author(s) 2013.
Chemical References
  • Acrylates
  • Imidazoles
  • Thiophenes
  • eprosartan
  • Acrylates (pharmacology, therapeutic use)
  • Aged
  • Aged, 80 and over
  • Blood Pressure (drug effects)
  • Cognition (drug effects)
  • Demography
  • Diastole (drug effects)
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Imidazoles (pharmacology, therapeutic use)
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Systole (drug effects)
  • Thiophenes (pharmacology, therapeutic use)

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