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Metabolic disease and participant age are independent predictors of response to pulmonary rehabilitation.

AbstractPURPOSE:
The study aims were (1) to determine whether baseline measures-including the Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity (BODE) index; Age, Dyspnea, and Airflow Obstruction (ADO) index; physical activity; comorbidities (cardiac, metabolic, or musculoskeletal disease); and the number of hospitalizations over the previous 12 months-can predict responders in 6-minute walk distance (6MWD) following pulmonary rehabilitation (PR) and (2) to determine whether different methods in defining improvement in 6MWD affected identifying responders to PR.
METHODS:
All participants with chronic obstructive pulmonary disease who attended PR at our institution between 2004 and 2009 were evaluated. A participant was classified as a responder with improvement in 6MWD (≥25 m or ≥2 SD of this dataset coefficient of repeatability).
RESULTS:
A total of 203 participants (mean age, 68.2 ± 8.7 years; mean predicted forced expiratory volume in 1 second, 52.5 ± 22.4%) were analyzed. One hundred twenty participants (59.1%) had a comorbidity categorized as cardiac, metabolic, or musculoskeletal disease. The binary logistic regression models showed that younger participants (P ≤ .015) and, when using the coefficient of repeatability method (≥60.9 m), participants with metabolic disease (P = .040) were the only independent predictors of response. No other measure, including participant BODE or ADO index scores, contributed to either model.
CONCLUSION:
Identifying responders in exercise capacity following PR remains difficult, with only age and participants with metabolic disease identified as independent predictors.
AuthorsJames R Walsh, Zoe J McKeough, Norman R Morris, Angela T Chang, Stephanie T Yerkovich, Helen E Seale, Jenny D Paratz
JournalJournal of cardiopulmonary rehabilitation and prevention (J Cardiopulm Rehabil Prev) 2013 Jul-Aug Vol. 33 Issue 4 Pg. 249-56 ISSN: 1932-751X [Electronic] United States
PMID23748375 (Publication Type: Comparative Study, Journal Article)
Topics
  • Age Factors
  • Aged
  • Body Mass Index
  • Exercise Therapy (methods)
  • Exercise Tolerance (physiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Metabolic Syndrome (epidemiology, etiology)
  • Motor Activity (physiology)
  • Prevalence
  • Prognosis
  • Pulmonary Disease, Chronic Obstructive (complications, rehabilitation)
  • Queensland (epidemiology)
  • Retrospective Studies
  • Risk Factors

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