Lipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study.

Abstract

INTRODUCTION:

Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory marker associated positively with atherothrombotic risk. Whether Lp-PLA2 is related to risk of venous thromboembolism (VTE) is incompletely studied.

METHODS:

We assessed Lp-PLA2 activity in 10,687 Atherosclerosis Risk in Communities (ARIC) Study participants and followed them a median of 8.3 years (from 1996-98 through 2005) for VTE occurrence (n=226).

RESULTS:

There was no significant association between baseline Lp-PLA2 quartiles and risk of VTE, neither overall nor stratified as provoked or unprovoked. Adjusted for other risk factors, the hazard ratios (95% confidence interval) of total VTE across quartiles of Lp-PLA2 were 1.0 (reference), 0.95 (0.64, 1.42), 1.03 (0.69, 1.56), and 1.26 (0.83, 1.91). In the subset of participants with LDL-cholesterol ≥130 mg/dL, hazard ratios of total VTE were 1.00, 1.39 (0.44, 4.44), 2.45 (0.84, 7.11), and 2.84 (0.99, 8.14).

CONCLUSION:

Our study does not support the overall hypothesis that elevated Lp-PLA2 contributes to VTE occurrence in the general population. However, in the presence of high LDL-cholesterol there was some evidence that Lp-PLA2 may increase VTE risk.

• Authors: Aaron R Folsom, Pamela L Lutsey, Nicholas S Roetker, Christie M Ballantyne, Ron C Hoogeveen, Wayne D Rosamond, Mary Cushman, Atherosclerosis Risk in Communities (ARIC) Study
• Journal: Thrombosis research (Thromb Res) Vol. 132 Issue 1 Pg. 44-6 (Jul 2013) ISSN: 1879-2472 [Electronic] United States
• PMID: 23746626 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Cholesterol, LDL
• 1-Alkyl-2-acetylglycerophosphocholine Esterase

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood, metabolism)
• Aged
• Cholesterol, LDL (blood)
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Risk Factors
• Venous Thromboembolism (blood, enzymology, etiology)