Further characterization of three Yersinia enterocolitica strains with a nalidixic acid-resistant phenotype isolated from humans with diarrhea.

Abstract

Antimicrobial-resistant bacteria pose a threat to public health. Three Yersinia enterocolitica strains cultured from patients presenting with diarrhea and resistant to nalidixic acid were studied. Target gene mutations in gyrA alone were identified as part of the genetic basis for this phenotype. Efflux activity was also noted, since the presence of the efflux pump inhibitor, phenylalanine-arginine-β-naphthylamide, increased susceptibility to nalidixic acid.

• Authors: Niall Drummond, Roger Stephan, Pippa Haughton, Brenda P Murphy, Séamus Fanning
• Journal: Foodborne pathogens and disease (Foodborne Pathog Dis) Vol. 10 Issue 8 Pg. 744-6 (Aug 2013) ISSN: 1556-7125 [Electronic] United States
• PMID: 23746356 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Dipeptides
• RNA, Bacterial
• RNA, Ribosomal, 16S
• Virulence Factors
• phenylalanine arginine beta-naphthylamide
• Nalidixic Acid
• DNA Gyrase

Topics

• Anti-Bacterial Agents (pharmacology)
• DNA Gyrase (genetics, metabolism)
• Diarrhea (microbiology)
• Dipeptides (metabolism)
• Drug Resistance, Multiple, Bacterial (genetics)
• Humans
• Microbial Sensitivity Tests
• Mutation
• Nalidixic Acid (pharmacology)
• Phenotype
• Polymerase Chain Reaction
• RNA, Bacterial (genetics)
• RNA, Ribosomal, 16S (genetics)
• Sequence Analysis, DNA
• Virulence Factors (genetics)
• Yersinia enterocolitica (drug effects, genetics, isolation & purification)