Increased levels of cell-free human placental lactogen mRNA at 28-32 gestational weeks in plasma of pregnant women with placenta previa and invasive placenta.

Abstract

We compared the levels of cell-free human placental lactogen (hPL) messenger RNA (mRNA) in maternal plasma at 28 to 32 weeks of gestation between women with diagnosis of placenta previa or invasive placenta and women with an uneventful pregnancy. Sensitivity and specificity of hPL mRNA for the prediction of invasive placenta were further explored. Plasma hPL mRNA were quantified by real-time reverse-transcriptase polymerase chain reaction in women with placenta previa (n = 13), invasive placenta (n = 5), and normal pregnancies (n = 92). Median (range) hPL mRNA was significantly higher in women with placenta previa, 782 (10-2301) copies/mL of plasma, and in those with invasive placenta, 615 (522-2102) copies/mL of plasma, when compared to normal pregnancies, 90 (4-4407) copies/mL of plasma, P < .01 and P < .05, respectively. We found a sensitivity of 100% and a specificity of 61.5% for the prediction of invasive placenta among women with placenta previa. In conclusion, expression of hPL mRNA is increased in plasma of women with placenta previa and invasive placenta at 28 to 32 weeks of gestation.

• Authors: Akihiro Kawashima, Akihiko Sekizawa, Walter Ventura, Keiko Koide, Kyouko Hori, Takashi Okai, Yoshida Masashi, Kenichi Furuya, Yoshifumi Mizumoto
• Journal: Reproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 21 Issue 2 Pg. 215-20 (Feb 2014) ISSN: 1933-7205 [Electronic] United States
• PMID: 23744883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• RNA, Messenger
• Placental Lactogen

Topics

• Adult
• Biomarkers (blood)
• Case-Control Studies
• Cell-Free System
• Female
• Humans
• Placenta (metabolism, pathology)
• Placenta Previa (blood, diagnosis)
• Placental Lactogen (blood)
• Pregnancy (blood)
• RNA, Messenger (blood)
• Young Adult