Abstract | BACKGROUND: METHODS: We measured the plasma bacterial DNA level in the archive blood samples of 300 consecutive new PD patients. The result was compared with serum C-reactive protein (CRP) level, patient survival and peritonitis-free survival. RESULTS: The average age was 57.8 ± 12.1 years, average plasma bacterial DNA level 34.3 ± 1.3 cycles and average follow-up 37.9 ± 22.2 months. The plasma bacterial DNA level correlated with serum CRP (r = 0.565, P < 0.001) and LPS levels (r = 0.224, P = 0.029). At 36 months, the patient survival were 77.5, 78.3, 74.6 and 65.2% for plasma bacterial DNA level quartiles I, II, III and IV, respectively (log-rank test, P = 0.034). By multivariate analysis with the Cox proportional hazard model to adjust for confounders, the plasma bacterial DNA level had no independent effect. Similarly, peritonitis-free survival were 60.6, 59.8, 60.3 and 50.4% for plasma bacterial DNA level quartiles I, II, III and IV, respectively, at 36 months (P = 0.020), and the difference was not significant after adjusting for confounding factors. CONCLUSION: We found that the plasma bacterial DNA level correlated with the degree of systemic inflammatory state in PD patients. Although plasma bacterial DNA level seems to predict patient survival and peritonitis-free survival, the association disappears after adjusting for confounding factors. Further prospective studies are needed to delineate the role of plasma bacterial DNA as a prognostic marker of renal failure patients.
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Authors | Bonnie Ching-Ha Kwan, Kai-Ming Chow, Chi-Bon Leung, Man-Ching Law, Phyllis Mei-Shan Cheng, Vincent Yu, Philip Kam-Tao Li, Cheuk-Chun Szeto |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 28
Issue 8
Pg. 2139-45
(Aug 2013)
ISSN: 1460-2385 [Electronic] England |
PMID | 23743015
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- DNA, Bacterial
- Lipopolysaccharides
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Topics |
- Biomarkers
(blood)
- DNA, Bacterial
(blood)
- Endotoxemia
(blood, diagnosis, etiology)
- Female
- Follow-Up Studies
- Humans
- Inflammation
(blood, diagnosis, etiology)
- Lipopolysaccharides
(blood)
- Male
- Middle Aged
- Peritoneal Dialysis
(adverse effects)
- Peritonitis
(blood, diagnosis, etiology)
- Polymerase Chain Reaction
- Prognosis
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