Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice.

Abstract	The effect of hydroxypropyl methylcellulose (HPMC) on hepatic gene expression was analyzed by exon microarray and real-time PCR from livers of diet-induced obese (DIO) mice fed a high-fat (HF) diet supplemented with either 6% HPMC or 6% microcrystalline cellulose (MCC). HPMC-fed mice exhibited significantly reduced body weight gain (55% lower compared to MCC), liver weight (13%), plasma LDL-cholesterol concentration (45%), and HF diet-increased intestinal permeability (48%). HPMC significantly reduced areas under the curve for 2 h insulin and glucose responses, indicating enhanced insulin sensitivity and glucose metabolism. HPMC up-regulated hepatic genes related to fatty acid oxidation, cholesterol and bile acid synthesis, and cellular activation of glucocorticoid (bile acid recycling) and down-regulated genes related to oxidative stress, triglyceride synthesis, and polyunsaturated fatty acid elongation. In conclusion, HPMC consumption ameliorates the effects of a HF diet on intestinal permeability, insulin resistance, hepatic lipid accumulation, glucocorticoid-related bile acid recycling, oxidative stress, and weight gain in DIO mice.
Authors	Hyunsook Kim, Glenn E Bartley, Scott A Young, Kun-Ho Seo, Wallace Yokoyama
Journal	Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 61 Issue 26 Pg. 6404-11 (Jul 03 2013) ISSN: 1520-5118 [Electronic] United States
PMID	23742138 (Publication Type: Comparative Study, Journal Article)
Chemical References	Prebiotics Hypromellose Derivatives Cellulose Methylcellulose microcrystalline cellulose
Topics	Animals Cellulose (therapeutic use) Diet, High-Fat (adverse effects) Fatty Liver (etiology, prevention & control) Gene Expression Profiling Gene Expression Regulation Hypromellose Derivatives Insulin Resistance Intestinal Absorption Liver (enzymology, metabolism) Methylcellulose (analogs & derivatives, therapeutic use) Mice Non-alcoholic Fatty Liver Disease Obesity (diet therapy, etiology, metabolism, physiopathology) Prebiotics

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