Abstract | PURPOSE: Intractable neuropathic dynamic allodynia remains one of the major symptoms of human trigeminal neuropathy and is commonly accepted to be the most excruciatingly painful condition known to humankind. At present, a validated animal model of this disorder is necessary for efficient and effective development of novel drug treatments. Intracisternal strychnine in rats has been shown to result in localized trigeminal dynamic allodynia, thus representing a possible model of trigeminal neuralgia. The purpose of this study was to validate a mouse model of trigeminal glycinergic inhibitory dysfunction using established positive ( carbamazepine epoxide) and negative ( morphine) controls. METHODS: RESULTS: CONCLUSION: In this study, we have developed and validated a novel murine model of trigeminal dynamic allodynia induced by intracisternal strychnine. The use of mice to study trigeminal allodynia has many benefits, including access to a vast repository of transgenic mouse variants, ease of handling, low cost, and minimal variance of results. The present model may have utility in screening drug treatments for dynamic mechanical allodynia resulting from trigeminal neuropathies.
|
Authors | Il-Ok Lee, Ryan A Whitehead, Craig R Ries, Stephan K W Schwarz, Ernest Puil, Bernard A MacLeod |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 60
Issue 8
Pg. 780-6
(Aug 2013)
ISSN: 1496-8975 [Electronic] United States |
PMID | 23740428
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
|
Chemical References |
- Analgesics, Non-Narcotic
- Glycine Agents
- Narcotics
- Carbamazepine
- Morphine
- Strychnine
- carbamazepine epoxide
- Glycine
|
Topics |
- Analgesics, Non-Narcotic
(administration & dosage, pharmacology)
- Animals
- Carbamazepine
(administration & dosage, analogs & derivatives, pharmacology)
- Cerebrospinal Fluid
- Cisterna Magna
(drug effects)
- Disease Models, Animal
- Female
- Glycine
(pharmacology)
- Glycine Agents
(administration & dosage, adverse effects)
- Injections
- Injections, Subcutaneous
- Mice
- Morphine
(administration & dosage, pharmacology)
- Narcotics
(administration & dosage, pharmacology)
- Pain Measurement
- Random Allocation
- Single-Blind Method
- Strychnine
(administration & dosage, adverse effects)
- Trigeminal Neuralgia
(chemically induced, prevention & control)
|