Abstract | INTRODUCTION: AREAS COVERED: This review describes the pharmacology and clinical trials data for phentermine/ topiramate ER and its role in a complications-centric approach to medical care of the overweight and obese patient. EXPERT OPINION:
Phentermine/ topiramate ER is an effective and safe weight-loss medication that can produce and sustain approximately 10% loss of body weight. This is a landmark development in the pharmacotherapy of obesity. By offering an effective medical option to complement lifestyle and surgical approaches, phentermine/ topiramate ER enables a comprehensive medical model for obesity care. The overall approach to the overweight and obese patient should be to identify individuals who will benefit most from therapy based on cardiometabolic or mechanical complications, establish therapeutic targets and goals for ameliorating these complications and selecting the treatment modality and intensity for weight loss to achieve these goals. This complications-centric model emphasizes weight loss as a tool to ameliorate obesity-related complications and optimizes benefit/risk for achieving the best outcomes in overweight/obese patients.
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Authors | William Timothy Garvey |
Journal | Expert opinion on drug safety
(Expert Opin Drug Saf)
Vol. 12
Issue 5
Pg. 741-56
(Sep 2013)
ISSN: 1744-764X [Electronic] England |
PMID | 23738843
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Anti-Obesity Agents
- Delayed-Action Preparations
- Topiramate
- Fructose
- Phentermine
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Topics |
- Anti-Obesity Agents
(administration & dosage)
- Delayed-Action Preparations
- Fructose
(administration & dosage, analogs & derivatives)
- Humans
- Obesity
(drug therapy)
- Overweight
(drug therapy)
- Phentermine
(administration & dosage)
- Topiramate
- Weight Loss
(drug effects)
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