Abstract | OBJECTIVE: DESIGN: Clinical intervention trial with interruption of phentermine treatment in long-term patients. SUBJECTS: 269 obese, overweight or formerly obese subjects (age: 20-88 years, BMI: 21-74 kg m(-2)) treated with phentermine long-term (LTP, N=117), 1.1-21.1 years, or short-term ( ATP, N=152), 4-22 days, with phentermine doses of 18.75-112.5 (LTP) and 15-93.75 ( ATP) mg per day. MEASUREMENTS: Module K of the Mini International Neuropsychiatric Interview modified for phentermine (MINI-SUD), Severity of Dependence Scale (SDS), 45-item Cocaine Craving Questionnaire-NOW (CCQ-NOW) modified for phentermine (PCQ-NOW), and Amphetamine Withdrawal Questionnaire (AWQ) modified for phentermine (PWQ). RESULTS: MINI-SUD interviews were negative for phentermine abuse or psychological dependence in all LTP patients. SDS examination scores were low for all LTP and ATP patients, indicating they were not psychologically dependent upon phentermine. PCQ-NOW scores were low for all LTP and ATP patients, indicating neither short-term nor long-term phentermine treatment had induced phentermine craving. Other than an increase in hunger or eating, amphetamine-like withdrawal symptoms did not occur upon abrupt phentermine cessation as measured by sequential PWQ scores. CONCLUSIONS:
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Authors | E J Hendricks, M Srisurapanont, S L Schmidt, M Haggard, S Souter, C L Mitchell, D G De Marco, M J Hendricks, Y Istratiy, F L Greenway |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 38
Issue 2
Pg. 292-8
(Feb 2014)
ISSN: 1476-5497 [Electronic] England |
PMID | 23736363
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Appetite Depressants
- Phentermine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Appetite Depressants
(administration & dosage, adverse effects)
- Behavior, Addictive
(chemically induced)
- Drug Administration Schedule
- Female
- Guideline Adherence
- Humans
- Male
- Middle Aged
- Obesity
(drug therapy)
- Phentermine
(administration & dosage, adverse effects)
- Substance-Related Disorders
(etiology)
- Surveys and Questionnaires
- Time Factors
- United States
- United States Food and Drug Administration
- Weight Loss
(drug effects)
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