5-aminolevulinic acid based photodynamic therapy for basal cell carcinoma: a 10-years follow-up study.

Abstract

OBJECTIVE:

This article presents long-term follow-up after use of topical photodynamic therapy (PDT) for basal cell carcinoma. PDT is treatment option for different tumors, involving use of specific agent which is activated by visible light and results in tissue destruction.

MATERIALS AND METHODS:

Overall 20 patients with 29 tumors were treated at the Latvian Oncology Center. Two illumination techniques were used: superficial for smaller lesions and multifiber contact for nodular tumors. Clinical outcome was evaluated at 1, 7, 44 months and 10 years after procedure.

RESULTS:

By 10 year follow up, there were 2 tumor recurrences and in one case there was tumor residual tissue after first PDT treatment. Overall after ten years follow-up complete response was 80% of cases.

CONCLUSION:

Data in this study supports hypothesis that PDT could be used for the treatment of non-invasive (superficial and nodular) basal cell carcinoma. Results in this study correspond with similar long-term follow-up studies.

• Authors: Žans Griškjans, Aleksands Derjabo, Ingrīda Čēma
• Journal: Stomatologija (Stomatologija) Vol. 15 Issue 1 Pg. 32-6 ( 2013) ISSN: 1822-301X [Electronic] Lithuania
• PMID: 23732828 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Aminolevulinic Acid (therapeutic use)
• Carcinoma, Basal Cell (drug therapy)
• Female
• Follow-Up Studies
• Humans
• Kaplan-Meier Estimate
• Lasers, Semiconductor
• Latvia
• Male
• Middle Aged
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Skin Neoplasms (drug therapy)