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Recent advances in the diagnosis and therapy of peanut allergy.

Abstract
Peanut allergy is a life-threatening, IgE-mediated allergic disease. In developed countries, the prevalence rate of peanut allergy in school-aged children is reported to be in excess of 1% and continues to rise, representing a major public health concern. Peanut allergy is diagnosed on the basis of a relevant clinical history combined with results of skin-prick testing and/or peanut-specific IgE levels. A double-blind placebo-controlled oral food challenge is the gold standard for diagnosis. Currently, there is no approved treatment or disease-modifying therapy for peanut allergy. This review discusses recent advances in molecular diagnostic techniques for peanut allergy and highlights advances in peanut allergy therapeutics, discussing allergen-specific and allergen-nonspecific treatments that are currently in Phase I/II clinical trials.
AuthorsSaira Z Sheikh, A Wesley Burks
JournalExpert review of clinical immunology (Expert Rev Clin Immunol) Vol. 9 Issue 6 Pg. 551-60 (Jun 2013) ISSN: 1744-8409 [Electronic] England
PMID23730885 (Publication Type: Journal Article, Review)
Chemical References
  • Immunoglobulin E
Topics
  • Clinical Trials as Topic
  • Double-Blind Method
  • Humans
  • Immunoglobulin E (immunology)
  • Peanut Hypersensitivity (diagnosis, immunology, pathology, therapy)
  • Skin Tests

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