Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review.

Abstract

OBJECTIVE:

A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia.

DATA SOURCES:

Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®.

STUDY SELECTION:

Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents.

OUTCOME MEASURE:

Resolution of gynecomastia.

RESULTS:

A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed.

CONCLUSION:

Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.

• Authors: Oren Lapid, Jan J van Wingerden, Leon Perlemuter
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 26 Issue 9-10 Pg. 803-7 ( 2013) ISSN: 2191-0251 [Electronic] Germany
• PMID: 23729603 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Estrogen Antagonists
• Tamoxifen

Topics

• Adolescent
• Adolescent Development (drug effects)
• Estrogen Antagonists (adverse effects, therapeutic use)
• Evidence-Based Medicine
• Gynecomastia (drug therapy)
• Humans
• Male
• Off-Label Use
• Tamoxifen (adverse effects, therapeutic use)