Abstract | OBJECTIVE: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. DATA SOURCES: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®. STUDY SELECTION: OUTCOME MEASURE: RESULTS: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. CONCLUSION:
Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.
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Authors | Oren Lapid, Jan J van Wingerden, Leon Perlemuter |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
Vol. 26
Issue 9-10
Pg. 803-7
( 2013)
ISSN: 2191-0251 [Electronic] Germany |
PMID | 23729603
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Estrogen Antagonists
- Tamoxifen
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Topics |
- Adolescent
- Adolescent Development
(drug effects)
- Estrogen Antagonists
(adverse effects, therapeutic use)
- Evidence-Based Medicine
- Gynecomastia
(drug therapy)
- Humans
- Male
- Off-Label Use
- Tamoxifen
(adverse effects, therapeutic use)
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