Complex regulatory network of microRNAs, transcription factors, gene alterations in adrenocortical cancer.

Abstract

Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.

• Authors: Bo Zhang, Zhi-Wen Xu, Kun-Hao Wang, Tian-Cheng Lu, Ye Du
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 4 Pg. 2265-8 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23725124 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MicroRNAs
• Transcription Factors

Topics

• Adrenocortical Carcinoma (genetics, metabolism)
• Computational Biology
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Humans
• MicroRNAs (genetics)
• Transcription Factors (metabolism)