Abstract | PURPOSE: MATERIALS AND METHODS: We obtained 24 colorectal specimens after surgical excision from patients affected by colorectal cancer at different tumor stages. (1) H-MR spectoscopy (MRS) spectra were collected from two voxels, in proximity of the lesion and far from it, in each specimen with a preclinical scanner. We differentiated patients by pathological tumor stage, and we compared the chemical composition of adipose tissue between patient groups, both close the tumor and far from it. RESULTS:
Monounsaturated fatty acids (MUFA) close the lesion are increased at higher tumor stages, while MUFA far from the lesion do not follow this trend. This study is really explorative due to the small numbers of subjects and we are cautious on the interpretation of the results. However, the approach of the present work allows a further insight in the tumor characterization. CONCLUSION: Looking at the lipid tissue around a lesion through (1) H-MRS can return important information regarding its genesis and development.
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Authors | Elisa Mosconi, Annamaria Minicozzi, Pasquina Marzola, Claudio Cordiano, Andrea Sbarbati |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 39
Issue 2
Pg. 469-74
(Feb 2014)
ISSN: 1522-2586 [Electronic] United States |
PMID | 23723058
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Adipose Tissue
(physiopathology)
- Adiposity
- Aged
- Algorithms
- Colorectal Neoplasms
(physiopathology)
- Female
- Humans
- Lipids
(analysis)
- Magnetic Resonance Spectroscopy
(methods)
- Male
- Protons
- Reproducibility of Results
- Sensitivity and Specificity
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