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Genetic association of sirtuin genes and Parkinson's disease.

Abstract
Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegenerative disorders, such as PD. Although seven sirtuin family members have been identified (SIRT1-SIRT7) the relationship between sirtuins and PD in humans has not been established. Our aim was to investigate the association between sirtuin genes and risk of PD. We included 326 PD patients and 371 controls from southern Spain. Forty-one single nucleotide polymorphisms (SNPs) in sirtuin genes were genotyped in order to determine whether they were related to the risk of PD. These SNPs included Tag-SNPs, coding non-synonymous SNPs and SNPs affecting activity of microRNA binding sites. No relationship was found between these SNPs in sirtuin genes and PD. Our data indicate that variations in sirtuin genes do not affect the risk for PD, at least in our population.
AuthorsSilvia Jesús, Pilar Gómez-Garre, Fátima Carrillo, María T Cáceres-Redondo, Ismael Huertas-Fernández, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Laura Vargas-González, Manuel Carballo, Pablo Mir
JournalJournal of neurology (J Neurol) Vol. 260 Issue 9 Pg. 2237-41 (Sep 2013) ISSN: 1432-1459 [Electronic] Germany
PMID23719790 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Sirtuins
Topics
  • Genetic Predisposition to Disease (genetics)
  • Genotype
  • Humans
  • Middle Aged
  • Parkinson Disease (genetics)
  • Polymorphism, Single Nucleotide
  • Sirtuins (genetics)
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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