Abstract |
The present study was undertaken to investigate the sedative, analgesic and clinical effects of xylazine, medetomidine and dexmedetomidine with fentanyl as pre-anaesthetics in water buffaloes and to compare the dose-sparing effect of xylazine, medetomidine and dexmedetomidine on thiopental for induction and isoflurane for maintenance of anaesthesia in water buffaloes. Six male water buffaloes randomly received intravenous fentanyl (5.0 µg/kg body weight) and xylazine (0.05 mg/kg body weight), fentanyl (5.0 µg/kg body weight) and medetomidine (2.5 µg/kg body weight), fentanyl (5.0 µg/kg body weight) and dexmedetomidine (5.0 µg/kg body weight) at weekly intervals in groups I1, I2 and I3, respectively. After 15 min, the animals were restrained in right lateral recumbency and anaesthesia was induced by 5% thiopental sodium administered intravenously. The intubated animal was connected to the large animal anaesthesia machine and isoflurane in 100% oxygen (5 L/min) was insufflated for 60 min. The treatments were compared by clinicophysiological, haematobiochemical and haemodynamic parameters. Fentanyl- medetomidine and fentanyl- dexmedetomidine produced more cardiovascular depression during the pre-anaesthetic period but less depression of cardio-respiratory dynamics in the post induction and maintenance period. Quicker recovery was recorded in I2 and I3 groups. A lower dose of thiopental was required in group I3 (4.33 mg/kg ± 0.66 mg/kg) than in groups I2 (4.41 mg/kg ± 0.98 mg/kg) and I1 (4.83 mg/kg ± 0.79 mg/kg). The dose of isoflurane was less in group I3 (45.50 mL ± 5.45 mL) than in group I1 and I2 (48.66 mL ± 5.10 mL and 48.00 mL ± 6.38 mL). Better anaesthesia was recorded with fentanyl- dexmedetomidine- thiopental- isoflurane (group I3) than with fentanyl- medetomidine- thiopental- isoflurane (group I2) and fentanyl- xylazine- thiopental- isoflurane (group I1). Fentanyl- medetomidine and fentanyl- dexmedetomidine were better pre-anaesthetic agents in comparison to fentanyl- xylazine for thiopental and isoflurane anaesthesia. Fentanyl- dexmedetomidine- thiopental- isoflurane and fentanyl- medetomidine- thiopental- isoflurane produced effective surgical anaesthesia and were found to be safe, as cardio-pulmonary functions were well preserved during maintenance anaesthesia with no deleterious effect on vital organ functions in water buffaloes.
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Authors | Gyan D Singh, Prakash Kinjavdekar, Amarpal, Hari P Aithal, Abhijeet M Pawde, Malik M S Zama, Jasmeet Singh, Ramesh Tiwary |
Journal | Journal of the South African Veterinary Association
(J S Afr Vet Assoc)
Vol. 84
Issue 1
Pg. E1-E11
(Mar 18 2013)
ISSN: 2224-9435 [Electronic] South Africa |
PMID | 23718913
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adjuvants, Anesthesia
- Anesthetics, Inhalation
- Hypnotics and Sedatives
- Dexmedetomidine
- Isoflurane
- Medetomidine
- Fentanyl
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Topics |
- Adjuvants, Anesthesia
(administration & dosage, pharmacology)
- Anesthesia, Inhalation
(veterinary)
- Anesthetics, Inhalation
(administration & dosage, pharmacology)
- Animals
- Buffaloes
- Dexmedetomidine
(administration & dosage, pharmacology)
- Fentanyl
(administration & dosage, pharmacology)
- Heart Rate
(drug effects)
- Hypnotics and Sedatives
(administration & dosage, pharmacology)
- Isoflurane
(administration & dosage, pharmacology)
- Male
- Medetomidine
(administration & dosage, pharmacology)
- Respiration
(drug effects)
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