Abstract | OBJECTIVE: DESIGN: This is a secondary analysis of a randomised controlled trial in which women with diabetes received daily vitamins C and E, or placebo, from 8 to 22 weeks of gestation until delivery. SETTING: Twenty-five antenatal metabolic clinics across the UK (in north-west England, Scotland, and Northern Ireland). POPULATION: Pregnant women with type-1 diabetes. METHODS: Hp phenotype was determined in white women who completed the study and had plasma samples available (n = 685). MAIN OUTCOME MEASURE: RESULTS: Compared with Hp 2-1, Hp 1-1 (OR 0.59, 95% CI 0.30-1.16) and Hp 2-2 (OR 0.93, 95% CI 0.60-1.45) were not associated with significantly decreased pre-eclampsia risk after adjusting for treatment group and HbA1c at randomisation. Our study was not powered to detect an interaction between Hp phenotype and treatment response; however, our preliminary analysis suggests that vitamins C and E did not prevent pre-eclampsia in women of any Hp phenotype (Hp 1-1, OR 0.77, 95% CI 0.22-2.71; Hp 2-1, OR 0.81, 95% CI 0.46-1.43; Hp 2-2, 0.67, 95% CI 0.34-1.33), after adjusting for HbA1c at randomisation. CONCLUSIONS: The Hp phenotype did not significantly affect pre-eclampsia risk in women with type-1 diabetes.
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Authors | T L Weissgerber, R E Gandley, J M Roberts, C C Patterson, V A Holmes, I S Young, D R McCance, Diabetes and Pre-eclampsia Intervention Trial (DAPIT) Study Group |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 120
Issue 10
Pg. 1192-9
(Sep 2013)
ISSN: 1471-0528 [Electronic] England |
PMID | 23718253
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 RCOG. |
Chemical References |
- Antioxidants
- Haptoglobins
- Vitamin E
- Ascorbic Acid
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Topics |
- Antioxidants
(metabolism, therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Diabetes Mellitus, Type 1
(complications)
- Female
- Haptoglobins
(chemistry, metabolism)
- Humans
- Odds Ratio
- Oxidative Stress
(drug effects)
- Phenotype
- Pre-Eclampsia
(blood, etiology, prevention & control)
- Pregnancy
- Pregnancy in Diabetics
(blood)
- Risk Factors
- Vitamin E
(therapeutic use)
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