The use of probenecid to increase the serum amoxycillin levels in patients with bronchiectasis.

Abstract

Amoxycillin 3 g twice daily is effective in treating patients with bronchiectasis who have daily purulent sputum. However, it is a relatively expensive treatment if used for prolonged periods. This pilot study in six patients with bronchiectasis showed that the concurrent administration of probenecid with a smaller dose of amoxycillin produced similar clinical responses and pharmacokinetic profiles to those found with high dose amoxycillin alone. The amount of amoxycillin used was reduced by two thirds, producing a potential saving of approximately pound 1000 per patient per annum in those taking long term treatment.

• Authors: M B Allen, R W Fitzpatrick, A Barratt, R B Cole
• Journal: Respiratory medicine (Respir Med) Vol. 84 Issue 2 Pg. 143-6 (Mar 1990) ISSN: 0954-6111 [Print] England
• PMID: 2371437 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amoxicillin
• Probenecid

Topics

• Adult
• Aged
• Amoxicillin (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Bronchiectasis (drug therapy, metabolism)
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Probenecid (administration & dosage, adverse effects, pharmacology)