Monogenic autoinflammatory diseases: concept and clinical manifestations.

Abstract

The objective of this review is to describe the clinical manifestations of the growing spectrum of monogenic autoinflammatory diseases including recently described syndromes. The autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary "periodic fever syndromes", familial Mediterranean Fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency.

• Authors: Adriana Almeida de Jesus, Raphaela Goldbach-Mansky
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 147 Issue 3 Pg. 155-74 (Jun 2013) ISSN: 1521-7035 [Electronic] United States
• PMID: 23711932 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)
• Copyright: Published by Elsevier Inc.

Topics

• Cryopyrin-Associated Periodic Syndromes (genetics, immunology)
• Exanthema (genetics, immunology)
• Granuloma (genetics, immunology)
• Hereditary Autoinflammatory Diseases (genetics, immunology)
• Humans
• Skin Diseases (genetics, immunology)