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[Changes in weight and diabetes compensation (HbA1c) in patients with diabetes mellitus type 2 after adding exenatide (Byetta) to the current treatment in 28 diabetology departments in the Czech Republic -  BIBYII study (observations lasting 24 months)].

AbstractUNLABELLED:
BIBYII STUDY OBJECTIVE: To obtain experience with longterm (24 months) exenatide treatment (Byetta) in patients with diabetes mellitus type 2 from a common clinical practice of diabetology departments in the Czech Republic. TYPE OF OBSERVATION: Observational study conducted by a randomly selected group of outpatient medical practitioners from 28 diabetology departments in the Czech Republic. OBSERVED AND ASSESSED POPULATION: From the original population of 465 patients, who underwent a minimum of three months Byetta treatment, 169 patients (36.6%) remained during the second prolonged observation after 18 months, and 76 patients completed 24 months of uninterrupted Byetta treatment. The following basic information about the patients was collected: year of birth, sex, age when diabetes mellitus (DM) manifested, height, maximum weight before diabetes and when DM manifested. The study recorded the following values in three- month intervals: weight, waistline, glycated haemoglobin (HbA1c), and DM treatment. The population of the prolonged observation comprised 50.3% women and 49.7 % men, and the average age at the time of DM2 manifestation was 48.0 (20- 73 years).
RESULTS:
At the beginning of Byetta treatment, the average maximum BMI in the subpopulation observed for 24 months was 38.44; after 3, 6, 9, 12 and 24 months the following levels were measured, respectively: 36.79, 36.22, 35.91, 35.57 and 35.58. The original HbA1c level of 7.44% at the beginning of Byetta treatment decreased after 3, 6, 9, 12 and 24 months to 6.33, 5.98, 5.83, 5.86 and 5.93%.
CONCLUSION:
Adding Byetta to the currently applied treatment of obese patients with diabetes mellitus type 2 over a period of 24 months has led to an improvement in HbA1c level by 1.51%, and BMI level was reduced by 2.37 after two years of Byetta treatment.
AuthorsJ Perušičová, P Piťhová, I Haladová, A Pracovní Skupina Diabetologů, D Acsová, J Bělobrádková, A Belzová, K Berková, B Doležalová, H Dvořáková, K Hejnicová, M Hudcová, D Kallmünzerová, Z Krejsová, G Markofová, H Müllerová, K Owen, M Pelikánová, L Raclavská, E Račická, O Skarpová, A Váchová, A Veselá, J Vyoralová, J Brož, T Edelsberger, M Honka, T Hrdina, P Chmura, J Tosovsky
JournalVnitrni lekarstvi (Vnitr Lek) Vol. 59 Issue 4 Pg. 249-55 (Apr 2013) ISSN: 0042-773X [Print] Czech Republic
Vernacular TitleZměny hmotnosti a kompenzace diabetu (HbA1c) u nemocných s diabetes mellitus 2. typu po přidání exenatidu (Byetta) ke stávající léčbě ve 28 diabetologických ambulancích v ČR -  studie BIBYII (sledování 24 měsíců).
PMID23711049 (Publication Type: Journal Article)
Chemical References
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Peptides
  • Venoms
  • Exenatide
Topics
  • Adult
  • Aged
  • Diabetes Mellitus, Type 2 (blood, drug therapy)
  • Exenatide
  • Female
  • Glycated Hemoglobin (analysis)
  • Humans
  • Hypoglycemic Agents (therapeutic use)
  • Male
  • Middle Aged
  • Peptides (therapeutic use)
  • Venoms (therapeutic use)
  • Weight Loss
  • Young Adult

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