Abstract | OBJECTIVE: DESIGN: Single-center, open-label, 12-week study. PATIENTS: INTERVENTIONS: OUTCOME MEASURES: The primary efficacy measure was change from baseline to week 12 (end of study) on question #5 ("average pain") of the Brief Pain Inventory (BPI). Secondary measures included least pain, worst pain, current pain, and sleep interference on the BPI, as well as the Pain Quality Assessment Scale (PQAS) and patient global assessment of treatment satisfaction. RESULTS: Thirty patients were enrolled and received $1 dose of OROS hydromorphone ER, titrated to a final mean dose of 26.4 mg/d. Mean (SE) BPI change from baseline to end of study was -1.3 (0.59) for current pain (p < 0.05) and -1.8 (0.61) for worst pain (p < 0.01). Mean (SE) change from baseline was also significant for BPI scores for sleep interference (-1.7 [0.61]; p < 0.01) and PQAS scores (-24.8 [7.9], p < 0.01). The majority (81 percent) of patients were satisfied or very satisfied with treatment. The most common treatment-related adverse events were dizziness, headache, and nausea (two patients each). CONCLUSIONS:
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Authors | Srinivas Nalamachu, Donna Ruck, Rahul Nalamasu, Sam Fasbinder, Ritvik Bansal |
Journal | Journal of opioid management
(J Opioid Manag)
2013 Jan-Feb
Vol. 9
Issue 1
Pg. 43-9
ISSN: 1551-7489 [Print] United States |
PMID | 23709303
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Delayed-Action Preparations
- Tablets
- Hydromorphone
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Topics |
- Administration, Oral
- Aged
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Chemistry, Pharmaceutical
- Chronic Pain
(diagnosis, drug therapy)
- Delayed-Action Preparations
- Drug Administration Schedule
- Drug Substitution
- Female
- Humans
- Hydromorphone
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Neuralgia
(diagnosis, drug therapy)
- Pain Measurement
- Patient Satisfaction
- Severity of Illness Index
- Surveys and Questionnaires
- Tablets
- Time Factors
- Treatment Outcome
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