Abstract |
Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA virus infection while IFITs sequester viral RNAs to exert an anti-viral effect. Notably, the structures of these proteins reveal both similarities and differences, which are suggestive of independent evolution towards ligand binding. 5'-triphosphates, which are absent from most RNAs in the cytosol of uninfected cells, are thus a marker of virus infection that is targeted by the innate immune system for both induction and execution of the anti-viral response.
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Authors | Jan Rehwinkel, Caetano Reis e Sousa |
Journal | Current opinion in microbiology
(Curr Opin Microbiol)
Vol. 16
Issue 4
Pg. 485-92
(Aug 2013)
ISSN: 1879-0364 [Electronic] England |
PMID | 23707340
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Carrier Proteins
- RNA, Viral
- RNA-Binding Proteins
- DEAD-box RNA Helicases
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Topics |
- Animals
- Carrier Proteins
- DEAD-box RNA Helicases
- Humans
- Immunity, Innate
- RNA Viruses
(immunology)
- RNA, Viral
(immunology, metabolism)
- RNA-Binding Proteins
(metabolism)
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