HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study.

AbstractBACKGROUND AND AIM:
Current treatment for irritable bowel syndrome (IBS) is suboptimal. Fermentable oligo-, di-, mono-saccharides and polyols (FODMAPs) may trigger gastrointestinal symptoms in IBS patients. Our aim was to determine whether a low FODMAP diet improves symptoms in IBS patients.
METHODS:
Irritable bowel syndrome patients, who had performed hydrogen/methane breath testing for fructose and lactose malabsorption and had received dietary advice regarding the low FODMAP diet, were included. The effect of low FODMAP diet was prospectively evaluated using a symptom questionnaire. Furthermore, questions about adherence and satisfaction with symptom improvement, dietary advice and diet were assessed.
RESULTS:
Ninety patients with a mean follow up of 15.7 months were studied. Most symptoms including abdominal pain, bloating, flatulence and diarrhoea significantly improved (p < 0.001 for all). 75.6%, 37.8% and 13.3% of patients had fructose, lactose malabsorption or small intestinal bacterial overgrowth respectively. Fructose malabsorption was significantly associated with symptom improvement (abdominal pain odds ratio (OR) 7.09 [95% confidence interval (CI) 2.01-25.0], bloating OR 8.71 (95% CI 2.76-27.5), flatulence OR 7.64 (95% CI 2.53-23.0) and diarrhoea OR 3.39 (95% CI 1.17-9.78), p < 0.029 for all). Most patients (75.6%) were adherent to the diet, which was associated with symptom improvement (abdominal pain, bloating, flatulence and diarrhoea all significantly associated with adherence, r > 0.27, p < 0.011). Most patients (72.1%) were satisfied with their symptoms.
CONCLUSIONS:
The low FODMAP diet shows efficacy for IBS patients. The current strategy of breath testing and dietary advice provides a good basis to understand and adhere to the diet.
AuthorsR H de Roest, B R Dobbs, B A Chapman, B Batman, L A O'Brien, J A Leeper, C R Hebblethwaite, R B Gearry
JournalInternational journal of clinical practice (Int J Clin Pract) Vol. 67 Issue 9 Pg. 895-903 (Sep 2013) ISSN: 1742-1241 [Electronic] India
PMID23701141 (Publication Type: Evaluation Study, Journal Article, Observational Study)
Copyright© 2013 John Wiley & Sons Ltd.
Chemical References
  • Fructose
  • Lactose
Topics
  • Abdominal Pain (diet therapy, etiology)
  • Breath Tests
  • Diarrhea (diet therapy, etiology)
  • Female
  • Flatulence (diet therapy, etiology)
  • Fructose (pharmacokinetics)
  • Fructose Intolerance (complications, diet therapy)
  • Humans
  • Irritable Bowel Syndrome (diet therapy, etiology)
  • Lactose (pharmacokinetics)
  • Lactose Intolerance (complications, diet therapy)
  • Malabsorption Syndromes (complications, diet therapy)
  • Male
  • Middle Aged
  • Patient Compliance
  • Patient Satisfaction
  • Prospective Studies
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: