Abstract | OBJECTIVE: To evaluate the relationship between multiple MR perfusion parameters and symptoms of patients with osteoid osteomas after percutaneous laser therapy. METHODS: MR perfusion studies of 20 patients diagnosed with an osteoid osteoma, treated with CT-guided percutaneous laser therapy, were retrospectively evaluated. Multiple perfusion parameters correlated with the treatment outcome and the presence of osteoid osteoma-related symptoms. RESULTS: There were 16 successful treatments, 6 recurrences and a significant difference in the perfusion parameters of these groups (P < 0.0001). Patients with successful treatment demonstrated delayed progressive enhancement or no enhancement (mean time to peak = 182 s, mean delay to the arterial peak = 119.3 s). Patients with treatment failure demonstrated an early and steep enhancement (mean time to peak = 78 s and mean delay to the arterial peak = 24 s). Plasmatic volume and transfer constant values significantly changed after successful treatment (P < 0.008). MR perfusion has a sensitivity and a specificity higher than 90 % in the detection of recurrent osteoid osteomas. CONCLUSION: The identification of an early and steep enhancement with short time to peak and a short delay between the arterial and nidus peaks on MR perfusion in the postoperative setting is highly indicative of an osteoid osteoma recurrence. Key points • Magnetic resonance perfusion is becoming widely used for several tumours. • MR perfusion measurements correlate well with osteoid osteoma-related symptoms. • MR perfusion has high diagnostic performance for osteoid osteoma recurrence. • MR perfusion can improve the diagnostic confidence of osteoid osteoma recurrence.
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Authors | Pedro A Gondim Teixeira, Anne Chanson, Marine Beaumont, Sophie Lecocq, Matthias Louis, Béatrice Marie, François Sirveaux, Alain Blum |
Journal | European radiology
(Eur Radiol)
Vol. 23
Issue 9
Pg. 2602-11
(Sep 2013)
ISSN: 1432-1084 [Electronic] Germany |
PMID | 23695220
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Bone Neoplasms
(diagnosis, pathology, therapy)
- Female
- Humans
- Image Processing, Computer-Assisted
(methods)
- Imaging, Three-Dimensional
(methods)
- Laser Therapy
(methods)
- Lasers
- Magnetic Resonance Imaging
(methods)
- Male
- Osteoma, Osteoid
(diagnosis, pathology, therapy)
- Perfusion
- Recurrence
- Sensitivity and Specificity
- Software
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
- Young Adult
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