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Dynamic MR imaging of osteoid osteomas: correlation of semiquantitative and quantitative perfusion parameters with patient symptoms and treatment outcome.

AbstractOBJECTIVE:
To evaluate the relationship between multiple MR perfusion parameters and symptoms of patients with osteoid osteomas after percutaneous laser therapy.
METHODS:
MR perfusion studies of 20 patients diagnosed with an osteoid osteoma, treated with CT-guided percutaneous laser therapy, were retrospectively evaluated. Multiple perfusion parameters correlated with the treatment outcome and the presence of osteoid osteoma-related symptoms.
RESULTS:
There were 16 successful treatments, 6 recurrences and a significant difference in the perfusion parameters of these groups (P < 0.0001). Patients with successful treatment demonstrated delayed progressive enhancement or no enhancement (mean time to peak = 182 s, mean delay to the arterial peak = 119.3 s). Patients with treatment failure demonstrated an early and steep enhancement (mean time to peak = 78 s and mean delay to the arterial peak = 24 s). Plasmatic volume and transfer constant values significantly changed after successful treatment (P < 0.008). MR perfusion has a sensitivity and a specificity higher than 90 % in the detection of recurrent osteoid osteomas.
CONCLUSION:
The identification of an early and steep enhancement with short time to peak and a short delay between the arterial and nidus peaks on MR perfusion in the postoperative setting is highly indicative of an osteoid osteoma recurrence. Key points • Magnetic resonance perfusion is becoming widely used for several tumours. • MR perfusion measurements correlate well with osteoid osteoma-related symptoms. • MR perfusion has high diagnostic performance for osteoid osteoma recurrence. • MR perfusion can improve the diagnostic confidence of osteoid osteoma recurrence.
AuthorsPedro A Gondim Teixeira, Anne Chanson, Marine Beaumont, Sophie Lecocq, Matthias Louis, Béatrice Marie, François Sirveaux, Alain Blum
JournalEuropean radiology (Eur Radiol) Vol. 23 Issue 9 Pg. 2602-11 (Sep 2013) ISSN: 1432-1084 [Electronic] Germany
PMID23695220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Adult
  • Bone Neoplasms (diagnosis, pathology, therapy)
  • Female
  • Humans
  • Image Processing, Computer-Assisted (methods)
  • Imaging, Three-Dimensional (methods)
  • Laser Therapy (methods)
  • Lasers
  • Magnetic Resonance Imaging (methods)
  • Male
  • Osteoma, Osteoid (diagnosis, pathology, therapy)
  • Perfusion
  • Recurrence
  • Sensitivity and Specificity
  • Software
  • Tomography, X-Ray Computed (methods)
  • Treatment Outcome
  • Young Adult

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