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Expression of Lewis X is associated with poor prognosis in triple-negative breast cancer.

Abstract
The Lewis X (Le(X)) antigen is a prognostic marker in certain solid tumors and has been proposed as a therapeutic target. Immunohistochemical analyses were performed to retrospectively examine the prognostic impact of Le(X) expression in 158 patients with triple-negative breast cancer (TNBC). Twenty-three (14.5%) patients were Le(X)-positive. Multivariate analysis showed that Le(X) positivity was an independent poor prognostic factor for recurrence-free survival (RFS) and overall survival (OS) (P = .037 and P = .024, respectively). Le(X) expression was a prognostic factor for survival in stage I/II and stage III TNBCs. Subgroup analysis according to age showed that Le(X) positivity was only associated with poor RFS and OS in younger patients with TNBC (age < 50 years) (P < .001 and P < .001, respectively). Our results suggest that Le(X) expression is an independent prognostic factor for RFS and OS in younger patients with TNBC.
AuthorsYoung Wha Koh, Hee Jin Lee, Jin-Hee Ahn, Jong Won Lee, Gyungyub Gong
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 139 Issue 6 Pg. 746-53 (Jun 2013) ISSN: 1943-7722 [Electronic] England
PMID23690116 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Lewis Blood Group Antigens
  • Lewis X Antigen
Topics
  • Biomarkers, Tumor (biosynthesis)
  • Breast Neoplasms (immunology, mortality, pathology)
  • Disease-Free Survival
  • Female
  • Humans
  • Lewis Blood Group Antigens (immunology)
  • Lewis X Antigen (biosynthesis)
  • Middle Aged
  • Prognosis
  • Retrospective Studies

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