Abstract | PURPOSE, PATIENTS, AND METHODS: RESULTS: Our results confirm that FPA levels are elevated in most cancer patients. Following chemotherapy, FPA levels were further increased within 45 minutes (mean FPA = 5.2 ng/mL before chemotherapy versus 8.3 ng/mL after chemotherapy, p less than 0.01) and were accompanied by an increase in the FPA generation rate. Infusion of heparin prior to chemotherapy significantly lowered plasma FPA levels and abolished post- chemotherapy FPA generation. CONCLUSION: These data suggest that patients receiving chemotherapy express thrombin-like activity in plasma and, therefore, may be at risk for clinically significant intravascular activation of coagulation. Heparin diminished the laboratory evidence of this chemotherapy-related coagulopathy and may have a role in the prevention of thromboembolic disorders in some cancer patients undergoing cytotoxic therapy.
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Authors | R L Edwards, M Klaus, E Matthews, C McCullen, R D Bona, F R Rickles |
Journal | The American journal of medicine
(Am J Med)
Vol. 89
Issue 1
Pg. 25-8
(Jul 1990)
ISSN: 0002-9343 [Print] United States |
PMID | 2368789
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Fibrinopeptide A
- Fibrinogen
- Heparin
|
Topics |
- Antineoplastic Agents
(adverse effects, pharmacology)
- Fibrinogen
(metabolism)
- Fibrinopeptide A
(metabolism)
- Heparin
(pharmacology)
- Humans
- Neoplasms
(blood, drug therapy)
- Partial Thromboplastin Time
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